SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9de5a222fdb78fc219d4048b580f7e30f71dff86d214982a4c36d3316ef00280' 
  AND token = 'pgusegO3VxE1WWnxOigU+XKXdUrOKLVJ0u4qZrxsmPI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}