SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ac21e4a22b15cbf895f6069e1606f622897061548f31c9ef1b2126bbdd648c35' 
  AND token = 'nSoOYxvckyF3Ogkt6TDY0gN484nsb6Dwgh9IMbJeVHI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}