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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e7c84bd97b3c8f69582009498d8ef0f41d9fd434a1329bc445b9d75d1daedf9' 
  AND token = 'O9YZ93MziQ6Y6uVqbexrDCiYrzBS0rBg4uY2GNWP8a0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}