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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '508734a7a8c80b46c9aa3b014f416e4308ecd9494149675fb2a0628ddeb6f0a1' 
  AND token = 'e+OiL+36EK8fgMUz79UMs1YYCywwK72V4yeccrvwSus=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}