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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0781343448ea5a2d22b5e3fbc128e874eb9d3369e42c26b17617011693e7f0f' 
  AND token = '2M+IQqM2nqZFEfspjiEv/Vyd4mRfueLe4WgNQ6uGKA4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}