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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50c5dade142d1f279d779594cf02ce296b946ee20722d7a87221030be2ac0469' 
  AND token = 'IHZt0y2H/W9pLV/F9/c73CgFiCOKSt4EZLsN/6ReQL4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}