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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f906d8cc16f133bf21a1150b0504eec7efbf58eef30dd9cc9495653c4e40c276' 
  AND token = 'vJ0S3YptZ0wpwPDgLI92GeHTbMLb2u8eDa+1Oyn47aE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}