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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1da0e09daa11e2e0c59f5d23d677b145f823d557136265b6ae48f83c16c316c' 
  AND token = 'ZhsojtP6f3OQE/tvPVppzmhoT24axUeYIX1NfaU9pmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}