SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd2ed3ce99e5568899114ead7f73dbdc754795b245b83ee29db3fe81917cd980f' 
  AND token = '59G7HhHRh8OHCytTVeVy5Tcjqb1Fmw0K5LAsmtGQD4s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}