SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f33350e65f2886ebde8cefb48e0df466ca320ff7d305844f0fdebedda4b8c996' 
  AND token = 'pJbfG9CxQ6OtKpVPvPE3UWYpSGmpT0q70KXAOWl1mVM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}