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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0621778f243be5f475ce21bebe48a593afd7f9c12f7d11d216f08f791197f813' 
  AND token = 'heYqiJ6BGXGk4DoZUmoe6oN7ykEM3uqrVEvS5ViU2sg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}