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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f35b52953800c13e726459ecd25bf941d2d1fee2a32be456213b9d1807d0cb78' 
  AND token = 'o3aM24dHzotP1k2yrfzqPvILdZ89LpW8tH9eJ0gwr8A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}