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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0450cadf613d30c22ab5956084e54909fc2ce6f932cd0bb92a2c8024d21c7137' 
  AND token = 'ke6aTUN1qyIIoNk7+zGMn30xrq3dFuYd1Vv9ve17DB4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}