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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd78ac1901387c679ff6926fda1824ce9a24c7ae422485eac77dd3b2f24111018' 
  AND token = 'dBBDvw4m5db8RCDYu/TDdEg15wvVMfe2rdCsVo2dua4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}