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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a5890b8104a40f53a12415f52f0814f67421f485a365e44cac8cc767996725' 
  AND token = '8s2DHKearoQjNMwcLrh7sRlCwnJX4clfMVZUXnqZvLY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}