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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c18d2a9da2f9cb0e7a89271862ea0cacec73ff832e28aeb9a6d7579f1d0731c' 
  AND token = 'lS4hb2uyHJx4Uwm23xgMTcYKU/JjmmYr0uQsYktvwuI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}