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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e1b00bf4369867927c937f45467190fdcaddc05c4e288bd90dbb19d307d9e52' 
  AND token = 'cIWuU4T1dQCMBHQSzUcmuNkehKh3FxFCc4SqCOQB9nM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}