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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '421a911d198443907d98868cc6b15e0bcd9c4e5fa29b66df9025d19696a624a5' 
  AND token = 'L5LHGd4xVEw3UBMSMtCegpcjpj+RD9QvL3Y8kYgRvZs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}