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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '449272bcd855422c7605d600a3620ff47263b9ebc5806873305f9ecfdd6af8f4' 
  AND token = 'gRMT5hYn2x7cuPu74q8OZKqUSbmSUaHgF28b2bdfD0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}