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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '201615307f2396dfe7f8409429fdb73f195b5101b591b054c4f179341347809d' 
  AND token = 'RDTyU43+JVUiWCr43aqvaFufnnAMwX7hLEkpsFioJX8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}