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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b6d3a991348e09583bc717aedcb709d83b61c311d9e19c83e51f4fbc7c6d965' 
  AND token = 'E2k+jMXbC94Ko3PIgp7nQfmFtBUzIN8d3Zqq1piFSb0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}