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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2270f7481ccf041fd88cad4bdbc7d8b25e4aa619a7421a5eabfbb9d632c473aa' 
  AND token = 'iytFge4c29opZKEI3Oq849N1L011ZKDtoJOvvdr2gBY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}