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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad18f9436deac4c3fb49b1ed181334ba35259755a25fe3268ae0474b70761405' 
  AND token = 'nuprj2HimK504yyxHM36X2SdbR9igcNoRROvBHpNNDk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}