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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '55aff343e4d0f91a4861e1a6e4fbfd56c293457d915450a0b1a5655533bb0303' 
  AND token = 'EEeOyJtbTJcWIpUJLBvBcS3I6wf+W/XLQ26oU3w/Ago=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}