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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f38953901bc28f31e6bba720c1e2668ea35dbbbd69e4c4d142cbf35ed92d1b8' 
  AND token = 'XMHO8XVLV4VUX1OhbhdurMFOY3GnpKOFotQ6xk+xT/c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}