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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b8bb86bb65adefa48f181b6ac2111194e3439d0feaee95faf075f21b547c40d' 
  AND token = 'kOvSPEItigG+aajry92grT4aJtxcTr5H82q/QwK3aco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}