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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4acc7ed4647ada5a792fa559bb300f7e22fb1ff4b4f2d5253527e61fbd0df01' 
  AND token = 'wxZirltjQL3XyX+tCbjlghYQ/cF2kbLjZ7dHZOywTSE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}