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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '146082048ed4492a0bb4f2012134b9bf8fa6181ad3ef89fd103853e1affdf04b' 
  AND token = 'k0NGiZ5Y196sonhL5SksD8KvofSncYMYYSrMxQa1oBY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}