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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '081e1c0a631b65d577d6585a12e29ff9970a3f589a80d3162c3bb468b47df254' 
  AND token = 'ROMuPyKery4hvy1TcZgqlFezdV1vkt8m1C84yDqyCLI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}