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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '38162999bcd3f7712835b44122788c58a6d619bf538e5b1fb8caddf2065fe028' 
  AND token = 'uBO2W0XmDuDLsoi2B1tb7a+O+n0rxKqBHh8UxF3jz8k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}