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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '376e467389663da92f166111fff8154c98b48229a5715aa874073df011807810' 
  AND token = 'zXM2INFNOl+slS5v6tA3r1LjkxrpJ4uFfGHa11SlkEo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}