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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '111b0ec9b0204fbf755ed651605ab317cc021066e084d1c9a3cd0aba82565f58' 
  AND token = 'PpZxyMHw9ac+WOIgTeR3sib6I1EVq3QIaUaGLJtLaXY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}