SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd81571fc93ca54d1f2edefb9645ac39e364bd27a7e4304451bca050477b30b42' 
  AND token = 'qs4MUN/UVEHW5gH5jnQxGoS1E+5x5L+b+AaqS0MfbY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}