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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64025d1c770fc706351089a4beece68cd5f339f697ec649f01b32e36172d536a' 
  AND token = 'UoIN2CNIDg9p2wKuGxRR4vFTtRMK4h7D47K/zQRQdGM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}