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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221214b6c0267140a2821addb59b39e5e03aeb33e1851995c00bd40b753f03ed' 
  AND token = 'mYNp5mAA1V1PvToZySGVlk3wQ426zWWpSp03MZ66x2k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}