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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '181eb0be3dc07b2ca281b6489f8b7e1159233bbc6aabea8771d0acc843c3cb1a' 
  AND token = 'ceenX99tVsg1otAUGjPY+DaaZBR54t5LXU5iDBgAxWA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}