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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '428d3072e6eb444862712ea96901ea8fa6ffe25ca34c385d88f3e8e42395b386' 
  AND token = '4ukiN+T6aY9hlcyaV2Is4BAzrWGFqIf+qnjJYR5hm1Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}