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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22da878ba75355183e362bc03c571c27d6ca5f1c7d194af5433f5280db5ed2fc' 
  AND token = 'lCGtEP/sLCCqs9BbUg3ZTd5/ETQIPqFEPChVLWfVrDo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}