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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e243c275d46c02194f634e4b634e42194ec2fde0fa868cc0a07810090b4fa814' 
  AND token = 'ZJYmkiVSz8LmRycs5mu1vgJ9cDDHV+9IAS0/YFAVb38=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}