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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e8576e9c03a0603563114f384cab87ac3846d948dab361560de863c11f3cb6' 
  AND token = '2Mz7Fb9r3qPDbpIcY7kJZ5tM3TXDpk1VJqUZuWzScyo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}