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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80f170646c8dfed6c0227976f1e1edcf281db3a0e721b34ada5b7fa388c1ded2' 
  AND token = 'Hv7rUt+8RcNAViDwU/0nt9Q5GE2i1znNKZUdm91ARo4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}