SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d1b7d8ee883c9a3807f546bc7afb181ab33d29c021cff9feeedf74bbc7cb966' 
  AND token = 'T0kpCu6z2IY94Ly6fW4Xm545IkKM1A2zCDk/hYBelQ4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}