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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b9ebf306be18f0d3ed7b0d11c188388190be0d40037567fac8ceace587ed611' 
  AND token = '4Uidxc1S9VIQ2isRmb65lmdWdbuQuw/pysAuIWAT72c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}