SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c67a0cc35d43a131b6209bcda1b122a90254edcc8fa50df9dea29538c1d40755' 
  AND token = 'YI+tHQhDFIx48XRi4NG1vFR2zeN6qDN4g9SmEM2OXxU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}