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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f715be7290ead75b69f519c03e2c3c531a903f2d287fb8a0793e799da00177c' 
  AND token = 'YuuDTTAydx8/BxbwVrWbiRVNk7SL2nEbWKfkSfBDOYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}