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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '647ffb28c0912f8264a66ffabf1cfc1aeafb48e3ce6e15a028ff4690df2b2553' 
  AND token = 'dR7n+1bJmYUFbQnYvpF1DiurAI4Euz7YdFbT8dvFfhM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00074

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}