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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43072dfe0c20eb1f1ae2c46afbf0d986efaf4fce7e2c1914782c9514eed5ae90' 
  AND token = 'IWzK8+pfNAQCb0eKPPTLyw/KACH1Nu/jHC3sjyDL0IQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}