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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00365bc2e2a84832403a3ae6c6ad1349769967880d89256b5240047fee09f6ce' 
  AND token = '+1WM0uhQKzgK0pCSnsNdT93FruBCbf0SnkpPFNF1cQA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}