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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d0c0c3696edf3d8123ff72b4d420894ce4e8da3ec5794d877b2e642fc935619' 
  AND token = '6kGxaNEOv5HqBAtJT7Nwlzy+qfnWPxsGSRbCVmcEr7o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}