SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ea6a933b9eda4a395a8b0c75e08e40d555a9dd8a8d010d7e0e790789c29609f' 
  AND token = '6n/JVKx2d8W0yMRYfsbcK6OeRDARVOBvEivf7SeKN30=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}